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The Flemington lab is engaged in research investigating the etiology and mechanisms of pathogen involvement in human diseases, with a special attention to viral associated cancers. Emphasis is on the role of herpesviral non-coding RNAs and their interactions with innate immune mechanisms, evasion of adaptive immunity in EBV associated cancers, and the development of genomics and transcriptomics tools to deal with the complexities of viral genomes.

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Selected Recent Lab Publications

 

-O'Grady, T, Wang, X, Honer Zu Bentrup, K, Baddoo, M, Concha, M, Flemington, EK. Global transcript structure resolution of high gene density genomes through multi-platform data integration. Nucleic Acids Res. 2016 Jul 12. Pii:gkw629. PMCID:

-Strong, MJ, Blanchard, # 4th, Lin, Z, Morris, CA, Baddoo, M, Taylor, CM, Ware, M, Flemington, EK. A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus-tumor association. Acta Neuropathol Commun. 2016 Jul 11;4(1):71. Doi: 10.1186/s40478-016-0338-z. PMCID: PMC4940872

-Lin, Z, Swan, K, Zhang, X, Cao, S, Brett, Z, Drury, S, Strong, MJ, Fewell, C, Puetter, A, Wang, X, Ferris, MB, Sullivan, DE, Li, L, Flemington, EK. Secreted oral epithelial cell membrane vesicles induce Epstein-Barr virus (EBV) reactivation in latently infected B-cells. J Virol. 2016 Jan 13;90(7):3469-79. doi: 10.1128/JVI.02830-15. PMCID: PMC4794692

-Strong MJ, Laskow T, Nakhoul H, Blanchard E, Liu Y, Wang X, Baddoo M, Lin Z, Yin Q, Flemington, EK. Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a, in EBV-Positive Gastric Carcinomas. J Virol. 2015 Oct;89(19):10110-4. doi: 10.1128/JVI.01110-15. Epub 2015 Jul 15. PMCID: PMC4577887

-Cao, S, Moss, W, O'Grady, C, Concha, M, Strong, MJ, Wang, X, Yu, Y, Baddoo, M, Zhang, K, Fewell, C, Lin, Z, Dong, Y, and Flemington, EK. New noncoding lytic transcripts derived from the Epstein Barr virus latency origin of replication oriP are hyperedited, bind the paraspeckle protein, NONO/p54nrb, and support lytic viral transcription. J Virol. 2015 Jul;89(14):7120-32. PMCID: PMC4473578

-Cao S, Strong MJ, Wang X, Moss WN, Concha M, Lin Z, O'Grady T, Baddoo M, Fewell C, Renne R, Flemington EK. High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the cancer cell line encyclopedia project. J Virol. 2015 Jan 1;89(1):713-29. PMCID: PMC4301145

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